|
KMID : 0613820100200111725
|
|
Journal of Life Science
2010 Volume.20 No. 11 p.1725 ~ p.1728
|
|
|
Normal Lung Ventilation/Perfusion Scintigraphy in Miniature Pigs
|
|
Kim Se-Eun
Han Ho-Jae
Shim Kyung-Mi
|
|
|
Abstract
|
|
|
|
Miniature pigs are widely used in experiments related to pulmonary disease because of their similarities with humans. However, there are not enough data about normal lung function in miniature pigs. Thus, in this study, we investigated normal lung function in miniature pigs with lung ventilation/perfusion scintigraphy and evaluated the availability of this method. Three male miniature pigs weighing 30-35 ㎏ were used. After general anesthesia, ventilation scintigraphy was performed with 100 MBq of 99mTc-pertechnetate (O₄?), after which perfusion scintigraphy was performed with intravenous injection of 99mTc-macro aggregated albumin (MAA). The functional contribution of the right lung was about 55%, and left lung was about 45%, similar to humans. Lung ventilation/perfusion scintigraphy was very useful in evaluating the normal lung function of miniature pigs because it was a non-invasive procedure (no tissue damage was involved), took a short time and was easy to perform. In conclusion, miniature pigs are similar to humans in functional contributions of the lung, and this method will be helpful in future pulmonary disease studies involving miniature pigs.
|
|
|
KEYWORD
|
|
|
99mTc-pertechnetate, 99mTc-macro aggregated albumin, lung ventilation-perfusion scintigraphy, miniature pig
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|